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Pharmacology

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Blood

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A 23-year-old pregnancy woman is referred by her obstetrician for evaluation of anemia. She is in her fourth month of pregnancy and has no history of anemia; her grandfather had pernicious anemia. Her hemoglobin is 10 g/dL (normal, 12-16 g/dL).


If this woman has macrocytic anemia, an increased serum concentration of transferrin, and a normal serum concentration of vitamin B12' the most likely cause of her anemia is deficiency of (LQ)



A Cobalamin
B Erythropoietin

C Folic acid
D Intrinsic factor

E Iron

Ans. C Folic acid

Deficiencies of folic acid or vitamin BIZ are the most common causes of megaloblastic anemia. If a patient with this type of anemia has a normal serum vitamin B12 concentration, folate deficiency is the most likely cause of the anemia.

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