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Pharmacology

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AIIMS Exam Questions

Question
4 out of 15
 

Antibiotic with time dependent killing with prolonged post antibiotic effect

 

A Clindamycin
B Erythromycin
C Beta lactam
D Fluoroquinolone
Ans. D Fluoroquinolones

The efficacy of antibiotics depends on the relationship of MIC (Minimum Inhibitory concentration) to various pharmacokinetic parameters e.g. Cmax (Max plasma concentration achieved), AUC and T (Time for which the concentration of antibiotic remains more than MIC).
 

Antibiotics with time dependent killing

Antibiotic with time dependent killing and postantibiotic effect

Antibiotics with post antibiotic effect

When the efficacy depends on the time the antibiotic’s plasma concentration remains more than MIC.

Hence these antibiotics require multiple dosing.

When the efficacy depends on the magnitude of total AUC (cumulative dose) as compared to MIC.

These antibiotics also require multiple dosing.

When the efficacy depends on the magnitude of Cmax as compared to MIC.

These antibiotics require single dosing.

Examples

Beta lactams

Flucytosine

Clindamycin

Erythromycin

Examples

Fluoroquinolones

Daptomycin

Examples

Aminoglycosides

Rifampin

Azithromycin

AIIMS Exam Questions Flashcard List

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