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Medicine

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Endocrine

Question
9 out of 20
 

'Hurthle cells' are seen in (LQ)



A Granulomatous Thyroiditis

B Hashimoto's Thyroiditis

C Papillary carcinoma of the thyroid

D Thyroglossal cyst

Ans. B

Hashimoto's Thyroiditis

Hashimoto’s thyroiditis (Chronic lymphocytic thyroiditis)

1). Most common auto immune cause of goitrous hypothyroidism. It is painless.

2). 20-60 yrs old women

3). Histology: Hurthle cells (cells with intensely eosinophilic, granular cytoplasm) are seen, diffuse parenchymal infiltration by lymphocytes.

4). Anti-thyroglobulin antibody and Thyroid peroxidase antibodies are present in the serum.

5). Antinuclear factor (ANF) may be positive.

6). Thyroxine therapy

7). May be associated with other autoimmune diseases (SLE, RA, SS [Sjogren's syndrome], etc.)

8). Complication: increased risk of non-Hodgkin‘ lymphoma (NHL) B cell lymphoma

PATTERNS OF THYROID FUNCTION TESTS

TSH

Free T4

T3

Diagnosis

Normal

Normal

Normal

Euthyroid

High

Low

low

Primary hypothyroidism

High

Normal

Normal

Subclinical hypothyroidism

Low

High

High

Hyperthyroidism

Low

Normal

Normal

Subclinical hyperthyroidism

Low

Normal

High

T3 toxicosis*

Low

Low

Low

Central hypothyroidism or sick euthyroid or drugs

Extra Edge: In Papillary carcinoma of the thyroid the macroscopic appearance of a papillary carcinoma with grossly discernible papillary structures is notable. The well-formed papillae, lined by cells with characteristic empty-appearing nuclei, sometimes termed "Orphan Annie eye" nuclei are characteristic. Cells obtained by fine-needle aspiration of a papillary carcinoma may characteristically show intranuclear inclusions.

Endocrine Flashcard List

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