CNS stimulants, used by youngsters to increase academic performance Can cause psychosis similar to paranoid schizophrenia
- Amphetamine is a powerful CNS stimulator. It acts on norepinephrine release in brain, along with an action on release of dopamine and serotonin. Amphetamine abuse may cause: -
- Acute intoxication: - Symptoms of acute intoxication are: -
- Cardiovascular: - Tachycardia, hypertension, Cardiac failure, Cardiovascular shock.
- CNS: - Euphoria, seizures, hyperpyrexia, tremors, ataxia, pupillary dilatation.
- Neuropsychiatric:- Anxiety, panic, insomnia, restlessness, irritability.
- Paranoid hallucinatory syndrome: - Closely mimics paranoid schizophrenia. It is also known as amphetamine psychosis. There may be idea of reference, delusion of persecution (AIlMS09), Auditory visual hallucination in a setting of clear consciousness.
- Chronic abuse: It causes
- Severe and compulsive craving for the drug.
- Cycle of 'runs' (heavy use for several days) followed by 'Crashes' (stopping the drug use).
- Tactile hallucination (formination).