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Biochemistry

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Carbohydrates

Question
6 out of 40
 

True about function of Thiamine is:

 

 
A It is required for the process of transamination
B It is cofactor in oxidative reduction

 

C It is coenzyme for transketolase
D It is coenzyme for pyruvate dehydrogenase and α keto dehydrogenase.
Ans. D It is coenzyme for pyruvate dehydrogenase and α Ketodehydrogenase. (Ref: Harper 29/E.)

a. Thiamine has a central role in energy-yielding metabolism and especially the metabolism of carbohydrates.

b. Thiamine diphosphate is the coenzyme for:

i. 3 multi enzyme complexes that catalyzes oxidative decarboxylation reactions.

Pyruvate dehydrogenase complex (catalyzes oxidative decarboxylation of pyruvate to acetyl-Co A)

α -ketoglutarate dehydrogenase in the citric acid cycle and

Branched chain keto-acid dehydrogenase involved in the metabolism of leucine, isoleucine and valine.

ii. Transketolase, in the pentose phosphate pathway.

a. The oxidative decarboxylation of pyruvate and α -ketoglutarateplaya key role in energy metabolism of most cells.

b. In thiamine deficiency, the activity of these two dehydrogenase reaction is decreased, resulting in a decrease production of ATP

Carbohydrates Flashcard List

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