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Biochemistry

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Carbohydrates

Question
32 out of 40
 

Which of the following is responsible for oxygen dependant killing? (AIPG 2007)

 

 
A Glutathione peroxidase
B NADPH oxidase
C Catalase
D Superoxide dismutase
Ans. B NADPH oxidase

"NADPH oxidase produces superoxide anion by a process of respiratory burst during phagocytosis".

"About 10% of O2 uptake by macrophages is used for free radicals generation. Along with activation of macrophages, the consumption of oxygen by the cell is increased drastically, this is called respiratory burst.

Rest 3 enzymes are involved in free radical scavenger system.

Superoxide dismutase

  1. Gene is on Chr 21
  2. Defect may cause Amyotropic lateral sclerosis
  3. 2 subtypes
  1. Cytoplasmic - Cu-Zn dependant
  2. Mitochondrial - Mndependant

 

Glutathione peroxidase

Selenium containing enzyme

catalase

2H2O2 --------- O2 + 2H2O

NADPH oxidase deficiency causes chronic granulo­matous disease.

Carbohydrates Flashcard List

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