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Medicine

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Rheumatology

Question
4 out of 12
 

14 yrs old girl on exposure to cold has pallor of extremities followed by pain and cyanosis. In later ages of life she is prone to develop? (AIIMS May 2011)



A SLE

B Scleroderma

C Rheumatoid arthritis

D Histiocytosis

Ans. B Scleroderma

1. "Raynaud's phenomenon, defined as episodic vasoconstriction in the fingers and toes, develops in virtually every patient with Systemic sclerosis. In some, episodes may also affect the tip of the nose and earlobes.

2. Attacks are triggered by

a. Exposure to cold b. Decrease in temperature

c. Emotional stress d. Using vibration tools

3. In colder climates, patients commonly experience an increase in the frequency and severity of episodes during the winter months.

a. Typical attacks start with pallor, followed by cyanosis of variable duration. Eventually erythema develops spontaneously or with rewarming of the digit.

b. The progression of the three color phases reflects the underlying pathogenic mechanisms of vasoconstriction, ischemia, and reperfusion.

c. Some patients with Raynaud's phenomenon may experience only pallor or cyanosis."

In a patient of Raynaud’s phenomena all arteries (like radial, brachial, popliteal, dorsalis pedis) are normally palpable.

Recent Advances:

a.Recently a new drug, Bosentan, which is a endothelin receptor blocking drug has been approve for the treatment of Raynaud’s phenomenon.

b. Extra Edge: Bosentan has also approved for the treatment of primary pulmonary arterial hypertension

Rheumatology Flashcard List

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