Oncology and Fibroids
35 yrs patient with nulliparous, primary infertility presents with mass. Her CA – 125 level is 90 U/L . Most likely cause? (AIIMS Nov 2010)
|C||Borderline ovary tumour|
1. This is a serum tumour marker that is elevated in 80% of patients with advanced ovarian cancer.
2. But this marker may also be elevated in pancreatic, gastric, colonic, and breast carcinoma; in non-malignant conditions such as benign cysts, endometriosis, pelvic inflammatory disease, and ascites; and in menstruation and pregnancy. Further, it may be normal in 50% of early stage ovarian cancer".
3. Patients with tuberculosis can have a tubo ovarian mass but they do not present with that mass as a symptom whereas endometriosis does
4. Ca 125 is elevated both in endometriosis and TB. In TB CA 125 is not taken as a primary investigation to diagnose TB, where as in endometriosis we do CA 125 levels regularly once we suspect this and then also as a follow up since this is a sensitive marker.