5. Edema is nephrotic syndrome is predominantly due to... (AIIMS Nov 10)
|A||Na & water restriction|
|B||Increased venous pressure|
|D||Increase capillary leakage|
Nephrotic Syndrome and Other Hypoalbuminemia States (Harrison, 18th, page 292)
a. The primary alteration in this disorder is a diminished colloid oncotic pressure due to losses of large quantities of protein into the urine.
b. With severe hypoalbuminemia and the consequent reduced colloid osmotic pressure, the NaCl and H2O that are retained cannot be restrained within the vascular compartment, and total and effective arterial blood volumes decline.
c. This process initiates the edema-forming sequence.