8-month boy baby is evaluated because of repeated episodes of pneumococcal pneumonia. Serum studies demonstrate very low levels of IgM, IgG, and IgA. This is related to a deficiency of which of the following? (AIIMS Nov 09)
|B||Class III MHC gene|
|C||Gamma chain of the IL-2 receptor|
As the history is of recurrent infections with bacteria (pneumococcal pneumonia), it indicates primary humoral immunodeficiency. As this is occurring in a 8-month old male child, it indicates X-linked agammaglobulinemia also called as burton’s agammaglobulinemia. In this disorder there is deficiency of the enzyme tyrosine kinase, which is required for B cell maturation.