A 10°C decrease in temperature causes decrease in cerebral metabolic rate by:
- Cerebral O2 consumption is 39% of normal (ie 61 % less than normal) at 30°C and 35% (ie 65% less) at 28oc.
- With each fall of 1°C metabolism is reduced by 6.7% so in 10oC fall it will decrease by 70%
- Other Effects' Q
R - Rise in S. K+Q
O – O2 dissociation curve shifted to left Q
A - Acidosis Q
D – Duration & magnitude of Block (N-M junction) by depolarizing drugs are increased and non depolarizing drug is reduced. Q