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Pathology

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Liver & Gall Bladder

Question
14 out of 45
 

A 20 yr old man with HBs Ag +re, HbeAg -ve with SGOT and SGPT raised 5 times the normal value. The HBV DNA copies are 1,00,000/ml. Which is the likely diagnosis? (LQ)



A Wild type HBV

B Surface mutant HBV

C PreCore mutant HBV

D Inactive HBV carrier

Ans. C preCore mutant HBV

The precore region directs the release of HBeAg towards secretion in the blood. Uncommonly, mutated strains called precore mutants of HBV emerge that do not produce HBeAg but are replication competent and express HBcAg. In these patients, the HBeAg may be undetectable despite the presence of HBV viral load. Another mutation in the core promoter region can also lead to an HBaAg negative phenotype. Clinically both these conditions are characterized by the presence of elevate liver enzymes and active viral multiplication is indicated only by the high levels of DNA polymerase.

Liver & Gall Bladder Flashcard List

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