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Medicine

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Hematology

Question
9 out of 10
 

A 20 yrs adult presents with severe hypoplastic anemia. What is most effective treatment: (LQ)



A α-interferon
B IL-2

C A TG therapy
D Bone marrow transplantation

Ans. D

Bone marrow transplantation

Treatment of aplastic anemia (Ref. Hari- 18th ed., Pg. 891)

1. Mild aplastic anemia

a. Antibiotic therapy: Fever of any sign of infection is an indication for empiric broad – spectrum antibiotic therapy.

b. Hematopoietic growth factors like GM – CSF, G – CSF, erythropoietin are given.

i- Supportive care ii- RBC transfusions as necessary iii- Platelet transfusions as necessary

2. Severe aplastic anemia

a. Neutrophil count <500/ml b. Platelet count <20,000/ml c. Reticulocytes <1% iv- BM cellularity <2%

i. Young adults (<50 yrs) who have HLA matched siblings

Treatment of choice is allogenic BM transplantation

ii. Adults (>50 yrs) OR Those without HLA matched sibling

Treatment of choice is immunosuppression with anti thymocyte globuli (ATG) plus cyclosporine

Hematology Flashcard List

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