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Dermatology

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Blistering Diseases

Question
29 out of 32
 

A 25-year-old female has palatal ulcers and blisters. The diagnosis is (AIIMS Nov 2012)



A Pemphigus vulgaris
B Pemphigus foliaceus

C Dermatitis herpetiformis
D Pemphigoid

Ans. A
[Pemphigus vulgaris]

Pemphigus volaris - The lesions are thin walled delicate blisters that usually rapidly rupture and rode.

They occur any were on the skin surface and very frequently occur within the mouth and throat Variants.

1). P. vegetans - more inflammatory component

2). P. foliaceous - rare, causes erosions and scaling rather than blister, no mucosal involvement

3). P. erythematosus - rare superficial type of pemphigus associated with SLE, it occurs around the face and scalp.

Differences between Pemphigus vulgaris and pemphigoid

P. vulgaris

Pemphigoid

Age

Middle age

60 – 80 years

Initial lesion at

Mucous membranes (mouth and throat)

Skin of legs à arm à head à trunk

Blister

Intraepidermal present

Subepidermal

Acantholysis

Present

Absent

Antibody

Against desmoglein (IgG)

Against basement membrane

Prognosis

Uniformly bad (mortality)

Bad only in old people.


Blistering Diseases Flashcard List

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