A 25 year old person comes with focal seizures, MRI shows frontal and temporal enhancement. What is the most probable diagnosis (AIPG 2010)
|B||Herpes simplex encephalitis|
Herpes simplex encephalitis
1). HSE result from primary HSV-1 infection, predominantly occurring under the age of 18; or over 50 years of age.
2). HSE is thought to be caused by the retrograde transmission of virus from a peripheral site on the face following HSV-1 reactivation, along a nerve axon, to the brain.
3). The virus lies dormant in the ganglion of the trigeminal cranial nerve,
4). The olfactory nerve may also be involved in HSE, which may explain its predilection for the temporal lobes of the brain, as the olfactory nerve sends branches there.
5). Without treatment, HSE results in rapid death in approximately 70% of cases.
6). MRI shows frontal and temporal lobe enhancement. (AIIMS May 2008)