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Pharmacology

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CNS Part- 2

Question
1 out of 42
 

A 26-yrs-old woman with reactive depression complains of missing her period and having milk discharge from her breasts. Pregnancy tests are negative. Which of the following is most likely to have caused these findings? (AIPG 2010)



A Amoxapine
B Clomipramine

C Fluoxetine
D Sertraline

Ans. A Amoxapine
  1. Amoxapine a tricyclic antidepressant, effectively blocks neuronal norepinephrine reuptake, is somewhat less potent in terms of blocking serotonin uptake, and is far less potent in terms of blocking dopamine reuptake.
  2. A metabolite of amoxapine blocks dopamine receptors quite well, and that effect makes it the most likely choice as the drug that caused the patient’s menstrual irregularities and galactorrhea.
  3. Drugs as the phenothiazine, which exert their main antipsychotic effects via blockade of dopamine receptors, may also cause amenorrhea, galactorrhea by the same mechanism, and drugs that activate dopamine receptors (e.g., bromocriptine) can be used to manage this endocrine dysfunction.
  4. Amoxapine’s dopamine receptor blockade also seems to account for why the drug exerts some antipsychotic properties, theoretically making it useful for patients with both psychosis and depression.

CNS Part- 2 Flashcard List

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