A 27-year-old sexually active male develops a vesiculobullous lesion on the glans soon after taking tablet paracetamol for fever. The lesion healed with hyperpigmentation. The most likely diagnosis is: (LQ)
|C||Fixed drug eruption|
Fixed drug eruption
1). Localized hyperpigmentation is seen as a side effect of several systemic medications, including those that produce fixed drug reactions (phenolphthalein, tetracyclines, sulfonamides, barbiturates, and analgesics) and those that can complex with melanin (antimalarials).
2). Fixed drug eruptions recur in the same location as circular areas of erythema that can become bullous and then resolve as hyperpigmented macules.
3). The eruption usually appears within hours of administration of the offending agent, and common locations include the genitalia, extremities, and perioral region.