A 4-yr boy comes for epistaxis. He has a H/O multiple bacterial and viral respiratory tract infections and eczema. An uncle had similar problems. Physical examination is remarkable for multiple petechial lesions on the skin and mucous membranes. Serum IgE is increased, and platelets are decreased. Most likely diagnosis?
This is the typical history of a immunodeficiency disorder Wiskott Aldrich syndrome.
This syndrome is characterized by thrombocytopenia, eczema, and recurrent sinopulmonary infections.
The patient has low levels of IgM and increased levels of IgG, IgA, and IgE.
The mode of inheritance is X-linked recessive.