A 45 year old female patient presents with symptoms of easy bruisability and frequent headaches. Physical examination show a moderate splenomegaly. Blood counts shows a normal leucocyte count and a platelet count of 1000 x 103 /cu mm. The leucocyte alkaline phosphatase score is normal. All of the following are drugs for the treatment of this patient except? (AIIMS Nov 2011)
2. Chemotherapy with hydroxyurea
3. Symptomatic thrombocytosis or splenomegaly can be treated with interferon alfa.
4. Anagrelide – a quinazoline derivative and platelet anti – aggregate that also lowers platelet count and can also control thrombocytosis.
5. Radioactive phosphorous
Recent Advances: Clinical trials testing the effect of JAK2 inhibitors (Lestaurtinib) are currently being performed.