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Medicine

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Hematology

Question
14 out of 34
 

A 45 year old female patient presents with symptoms of easy bruisability and frequent headaches. Physical examination show a moderate splenomegaly. Blood counts shows a normal leucocyte count and a platelet count of 1000 x 103 /cu mm. The leucocyte alkaline phosphatase score is normal. All of the following are drugs for the treatment of this patient except? (AIIMS Nov 2011)



A Hydroxyurea
B Radioactive phosphorus

C Anagrelide
D Bortezomid

Ans. D

Bortezomid

Management

1. Venesection

2. Chemotherapy with hydroxyurea

3. Symptomatic thrombocytosis or splenomegaly can be treated with interferon alfa.

4. Anagrelide – a quinazoline derivative and platelet anti – aggregate that also lowers platelet count and can also control thrombocytosis.

5. Radioactive phosphorous

Recent Advances: Clinical trials testing the effect of JAK2 inhibitors (Lestaurtinib) are currently being performed.

Hematology Flashcard List

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