A 45 year old male with history of smoking is scheduled for elective surgery. All of the following are true about the effects of smoking relevant to anaesthesia, except: (AIPG 2012)
|A||Nicotine resets the carotid and aortic bodies and increases the sympathetic tone|
|B||Carbon monoxide shifts the oxyhaemoglobin dissociation curve to the right|
|C||Smoking decreases surfactant levels|
|D||Dose requirement of aminosteroid muscle relaxants are increased in smokers|
Carbon monoxide shifts the oxyhaemoglobin dissociation curve to the right.
Carbon monoxide shifts the oxyhemoglobin dissociation curve to the left .This LEADS to decreased availability of oxygen to the tissue.
Stopping smoking eliminates the stimulus for the production of airway secretions and bronchoconstriction.
Time course Beneficial effect
12-24hrs Decreased CO AND NICOTINE LEVELS
48-72 hrs Decreased carboxyhemoglobin level significantly shift oxyhaemoglobin dissociation curve to the right. Reduced nicotine induced tachycardia.
Ciliary function also improved
2 wk Decreased sputum production
4-6 wk PFTs improved
6-8 wks immune function ventilation improved
8-12 wks decreased postoperative morbidity and mortality