A 45 yr old female is diagnosed having superficial, grade II transitional cell carcinoma of the urinary bladder. Which of the following is not true about regarding this patient?
|A||Smoking do not predispose to this cancer|
|B||Recurrence will occur for which she may need repeated fulguration|
|C||There are no effective anti-cancer drugs for bladder cancer|
|D||There is 70% chance that she eventually will need cystectomy in next 5 yrs.|
Harrison’s 18th/pg. 593
a. “A number of chemotherapeutic drugs in UB cancer have shown activity as single agents; cisplatin, paclitaxel, and gemcitabine are considered most active. Standard therapy consists of two-, three-, or four-drug combinations.
b. Overall response rates of >50% have been reported using combinations such as methotrexate, vinblastine, doxorubicin, and cisplatin (M-VAC); cisplatin and paclitaxel (PT); gemcitabine and cisplatin (GC); or gemcitabine, paclitaxel, and cisplatin (GTC).
c. The decision to administer adjuvant therapy is based on the risk of recurrence after cystectomy. Indications for adjuvant chemotherapy include the presence of nodal disease, extravesical tumor extension, or vascular invasion in the resected specimen.