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Dermatology

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Eczema

Question
6 out of 13
 

A 5 year old male child has multiple hyperpigmented macules over the trunk. On rubbing the lesion with the rounded end of a pen, he developed urticarial wheal, confined to the border of the lesion. The most likely diagnosis is - (AIIMS Nov 2013)



A Fixed drug eruption

B Lichen planus

C Urticaria pigmentosa

D Urticarial vasculitis

Ans. C
i.e., Urticaria pigmentosa

a. Urticaria pigmentosa is a familial cutaneous disorder characterised by generalized distribution of red brown macules.

b. Each lesion represents a collection of mast cells in the dermis with hyperpigmentation of overlying epidermis.

c. The most characteristic features is that these lesions urticate on scratching.

d. Light scratching with the point of forceps or rounded tip of a pen or even rubbing causes these mast cells to degranulate leading to localized urticaria (become red swollen and enlarged) à Darier’s sign.

e. Extensive release of histamine from mast cell degranulation may result in - Headache, flushing diarrhea and pruritis

Eczema Flashcard List

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