A 50 year old male, Ram Lal suffering from renal failure, underwent kidney transplant. He was prescribed a nucleotide derivative following the organ transplant. The nucleotide derivative of therapeutic importance in this organ transplant is (AIIMS Nov 2003)(DPG 2008)
· Immunosuppressants are used in organ transplantation to prevent the rejection. Most commonly used agents for this purpose are glucocorticoids.
· Azathioprine is a nucleotide derivative that can be used as an immunosuppressant.
· 5-Fluorouracil and cytarabine are also nucleotide derivatives but these are used for the treatment of cancers.
· Allopurinol is used to decrease the production of uric acid. It has no role in renal transplantation.