33 out of 42
A 55-year-old male accident victim in casualty ‘urgently’ needs blood. The blood bank is unable to determine his ABO group, as his red cell group and plasma group do not match. Emergency transfusion of patient should be with:
|A||RBC corresponding to his red cell group and colloids/crystalloid|
|B||Whole blood group corresponding to his plasma group|
|C||O Negative RBC and colloids/crystalloid|
|D||AB negative whole blood|
Ans. C O Negative RBC and colloids/crystalloid
- Dangerous hemolytic transfusion reactions occur when blood is transfused into an individual with an incompatible blood type (an individual who has agglutinins against the ABCs in the transfusion).
- The plasma in the transfusion is so diluted in the recipient that it rarely causes agglutination even when the titer of agglutinins against the recipient’s RBCs is high.
- However, when the recipient’s plasma has agglutinins against the donor s RBCs the cells agglutinate and hemolyze liberating free hemoglobin into the plasma.
- The seventy of transfusion reaction varies from an asymptomatic rise in plasma bilirubin to severe jaundice and renal tubular damage, with an anuria and death Type 0 individuals are ‘universal-donors’ because there are no regular anti-C agglutinins, and type O blood can be given to anyone without producing a transfusion reaction due to ABO incompatibility. Q
- This does not mean however that blood should ever be transfused without being cross-matched except in the most extreme emergencies since the possibility of reactions or sensitization due to incompatibilities other than ABC incompatibilities always exists.