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Medicine

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Respiratory

Question
22 out of 27
 

A 60 year old male was diagnosed as carcinoma right lung. On CECT chest there was a tumor of 5x5 cm in upper lobe and another 2x2 cm size tumor nodule in middle lobe. The primary modality of treatment is: (AIPG 2009)



A Radiotherapy

B Chemotherapy

C Surgery

D Supportive treatment

Ans. C

Surgery

Treatment: Non-small cell tumours: Excision is the treatmentQ of choice

Curative radiotherapy is an alternative if respiratory reserve is poor.

Chemotherapy + radiotherapy for more advanced disease.

Table 89–9 Drugs used in First-Line Chemotherapy for Metastatic Non-Small Cell Lung Cancer

(Ref. Hari-18th ed., Pg- 750)

1). Cisplatin

2). Paclitaxel

3). Gemcitabine

4). Docetaxel

5). Carboplatin

6). Vinorelbine

7). Irinotecan

8). Pemetrexed

9). Gefitinib

Treatment: Small Cell Lung Cancer

1). Cisplatin or carboplatin and Etoposide

2). Cyclophosphamide, doxorubicin, and vincristine

Recent advance: Newer drugs

Agents that Inhibit Angiogenesis (Ref. Hari -18th ed., Pg- 751-52)

Bevacizumab was the first antiangiogenic agent approved for the treatment of patients with advanced NSCLC. This drug primarily acts by sponging up VEGF and blocking the growth of new blood vessels, which are required for tumor viability.

Agents that Inhibit the Epidermal Growth Factor Receptor

1). Erlotinib and gefitinib are oral small-molecule kinase inhibitors that inhibit signaling via EGFR.

2). Cetuximab is an intravenously administered chimeric antibody directed against EGFR.

Prevention: Quit smoking, Q

Respiratory Flashcard List

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