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Medicine

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Kidney

Question
11 out of 11
 

A 7 yrs old girl is brought with complaints of generalized swelling of the body. Urinary examination reveals grade 3 proteinuria and the presence of hyaline and fatty casts. She has no history of hematuria. Which of the following statements about her condition is true- (AIIMS May 2011)



A No IgG deposits or C3 deposition on renal biopsy

B Her C3 levels will be low

C IgA nephropathy is the likely diagnosis

D Alport's syndrome is the likely diagnosis

Ans. A No IgG deposits or C3 deposition on renal biopsy

Ref. Robbins,8thed.,page 925,926

History indicates that the child is suffering from nephrotic syndrome. The most common cause of nephrotic syndrome in children is minimal change disease. Minimal change disease is characteristic used by

i. Diffuse effacement of foot processes of visceral epithelial cells (Podocytes) in the glomeruli that appear virtually normal by light microscopy

ii. Immunofluorescence studies show No Ig or complement deposits

iii. The glomeruli are normal by light microscopy. The cells of the PCT are often laden with lipid and protein, reflecting tubular reabsorption of lipoproteins, passing through diseased glomeruli (thus the historical name lipoid nephrosis for this disease)

iv. Clinically the child presents with aggressive proteinuria and there is commonly no hypertension or hematuria

v. The proteinuria is highly selective, most of protein having albumin

vi. Most children (90%)with minimal change disease respond rapidly to corticosteroid therapy

Kidney Flashcard List

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