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Hematology

Question
16 out of 19
 

A child presents with hypochromic microcytic anemia, with normal levels of free Erythrocyte Protoporphyrin The most likely diagnosis is: (DNB Dec 2009)



A Iron deficiency anemia
B Lead toxicity

C Thalassemia
D Anemia of chronic disease

Ans. C

Thalassemia

Diagnostic Features

1. Thalassanemia major

a. Profound hypochromic anemia, severe red cell dysplasia

b. Absence or severe reduction of HbA

c. NESTROFT test (AIIMS Nov 2011) – It is screening test for the detection of thalassanemia & common hemoglobinopathies-

d. Raised HbF (Most characteristic feature) in Hb electrophoresis (most important Test)

e. Family history showing both parents having thalassanemia minor.

Erythrocyte protoporphyrin levels are characteristically normal in Thalassemia

a. Free Erythrocyte Protoporphyrin is a useful screening test for microcytic hypochromic anemias.

b. Free Erythrocyte protoporphyrin levels are increased in iron deficiency anemias, lead poisoning many cases of sideroblastic anemia and anemias of chronic disease.

c. Erythrocyte protoporphyrin levels are normal in Thalassemias.

Parameter

Iron deficiency

Lead poisoning

Thalassemia trait

Chronic disease

Fee erythrocyte

Protoporphyrin (FEP)

ed

ed

Normal

ed

Hematology Flashcard List

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