Oncology and Fibroids
A female patient with 6x6 tumour, diagnosed to be granulosa cell tumour. which one of the following will you monitor for detection of recurrence what is the marker of granulosa cell tumour ? (AIIMS Nov. 2011)
|B||Ca 50 ldh|
1. Granulosa-theca cell tumors may develop in any age group. They account for ~5% of patients with precocious puberty (<9 years). If granulosa-theca tumors occur during the menstrual years, ~5% willcause amenorrhea and signs of estrogen excess. Because of tonically elevated and unopposed estrogen levels, ovulation is inhibited, and the proliferative endometrium may become hyperplastic.
2. Other symptomatology in the postmenopausal years is related to estrogen stimulation (breast soreness, fluid retention, nausea). The granulosa cell tumor is a low-grade malignancy.
3. In addition to endometrial hyperplasia, endometrial carcinoma may occur. Granulosa-theca cell tumors are usually yellow-orange and ~15 cm in diameter. Some may be microscopic. They usually are usually unilateral .They are bilateral in only 2% of patients.
4. The granulosa cells show a tendency to arrange themselves in small clusters or rosettes around a central cavity, so there is a resemblance to primordial follicles (i.e., Call-Exner bodies) Inhibin is secreted by some granulosa cell tumors and is a useful marker for the disease.
5. An elevated serum inhibin level in a premenopausal woman presenting with amenorrhea and infertility is suggestive of a granulosa cell tumor.