A female presents with history of progressive breathlessness. Histology shows heterogenous patchy fibrosis with several fibroblastic foci. The most likely diagnosis is - (AIPG, 2010)
|A||Cryptogenic organizing pneumonia|
|B||Non specific interstitial pneumonia|
|C||Usual interstitial pneumonia|
|D||Desquamative interstitial pneumonia|
' Hypersensitivity pneumonitis (also called allergic alveolitis) describes a spectrum of immunologicatly mediate4
predominantly interstitial lung disorders caused by intense, often prolonged exposure to inhaled organic antigens.
It is a type III + IV hypersensitivity reaction.
' Table 15-6 on page 697/8h Robbins mentions- Byssinosis is an organic dust causing asthma; rest of the options silicosis, asbestosis and berylliosis are Biven as examples of mineral dusts. So, they can be easily excluded. The best answer would therefore be option'c' i.e. Byssinosis.
Other examplee associated with hypersensitivity pneumonitis