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Paediatric

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Malignancies

Question
42 out of 61
 

A l-year-old child presented with a swelling in the left flank with episodes of flushing, diarrhea, sweating and bone pain. The diagnosis is - (AIPG 2012)



A Neuroblastoma
B Wilm'stumor.

C Medulloblastoma
D Pheochromocytoma

Ans. A

Neuroblastomal

Clinical manifestations of neuroblastoma

a. Because neuroblastoma arises from neural crest derivatives of sympathetic nervous system, it producecatechoiamines.

b. o So, it may cause clinical feature due to : -

1. Primary tumor

2. Metastais

3. Catecholamine secretion

Due to mass

Due to metastatic deposits

Due, to increased Catecholamine

secretion

o Abdominal swelling/lump n

in abdominal presentation

olocal compression effects eg. Respiratory embamassment and Cough in Mediastinal presentation

§ Orbital proptosis

§ Fever

§ Bone pain

§ Spinal cordcompression

Episodic diarrhea

Flushing

Tachycardia

Headache

Sweating

Uncommon features : - Opsoclonus or opsaffiyoclonus o Myasthenia gravis o Cranial involvement


The patient in question is a one year-old child presenting with all the characteristic features of neuroblastoma.

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