General Virology and DNA Viruses
A normally healthy 7-year-old girl is sent home from school with a suspected case of fifth disease as a result of her presenting with the initial symptoms of the infection. After being at home for a few days, her symptoms change indicating her transition into the second phase of the illness. Which of the following symptoms is the girl most likely experiencing during the second phase of parvoviral infection? (AIPG 2012)
The second stage of parvoviral B19 infection is immune-mediated, and results in formation of a lacy skin rash occurring first on the face and then moves to the extremities; answers A, B, C, incorrect
a. aplastic crisis occurs in hosts with sickle cell disease or other acquired hemolytic anemias, not in normally healthy individuals;
b. parvoviral infection does not cause gastrointestinal symptoms;
c. mild fever, not high fever, is a symptom that occurs in the initial stage of fifth disease.