Liver & GIT
A nursing student has just completed her hepatitis B vaccine series. On reviewing her laboratory studies (assuming she has no prior exposure to hepatitis B), you
|A||Positive test for hepatitis B surface antigen|
|B||Antibody against hepatitis B surface antigen (anti-HBS) alone|
|C||Antibody against hepatitis core antigen (anti-HBC)|
|D||Antibody against both surface and core antigen|
The current hepatitis B vaccine is genetically engineered to consist of hepatitis B surface antigen particles. Therefore, only antibody to surface antigen will be detected after vaccination. Since the patient has had no exposure to hepatitis B, she should be surface antigen–negative; surface antigen positivity means active disease, either acute or chronic. Patients who have recovered from hepatitis B have antibodies both to HBs and HBc.