Autocoids (Histamine and Serotonin)
A patient comes to you complaining that whenever he takes aspirin for headache, he develops severe shortness of breath. Which of the following may be partly responsible for this effect? (LQ)
Aspirin inhibits COX enzyme and results in the diversion of AA pathway towards L T synthesis. As LTs are powerful bron- choconstrictor agents, these may result in the shortness of breath in patients who are susceptible. Aspirin acetylated COX starts producing lipoxins (known as aspirin triggered lipoxins) that also have bronchoconstrictor properties.