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Medicine

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Hematology

Question
6 out of 19
 

A patient presents with increased serum iron, decreased TIBC, increased percent saturation and increased serum ferritin. Most probable diagnosis is:



A Anemia of chronic disease:
B Sideroblastic anemia

C Iron deficiency anemia
D Thalassemia minor

Ans. D

Thalassemia minor

Thalassanemia minor: Clinical feature

1. Mild anemia, microcytic hypochromic RBCS (total iron binding capacity, serum iron, ferritin levels are normal)

2. Some target cells, punctate basophilia

3. Raised HbA2 4 –6% (normal HbA2 1.5 to 3%)

4. Family history with one parent having thalassanemia minor.

Management of thalassemia major

1. Regular blood transfusion to maintain hematocrit in the range of 30 – 35% or Hb in the range

2. of 10 gm%

3. Allogeneic bone marrow transplantation for erythropoietic failure.

4. Avoid iron therapy. Desferrioxamine is used as an iron chelating agent.

5. Splenectomy if hypersplenism occurs.

6. Give folate supplementation

7. Manipulation of globin chain expression and gene therapy.

Hematology Flashcard List

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