A patient with AIDS is treated with a combination of agents, one of which is zidovudine. This drug exerts its main effects by inhibiting which of the following?
|A||Nonnucleoside reverse transcriptase|
|B||Nucleoside reverse transcriptase|
|D||Viral particle assembly|
a. Zidovudine competitively inhibits HIV-1 nucleoside reverse transcriptase. It is also incorporated in the growing viral DNA chain to cause termination.
b. Each action requires activation via phosphorylation of cellular enzymes. Zidovudine decreases the rate of clinical disease progression and prolongs survival in HIV-infected patients.