A patient with an infectious disease is being treated with an aminoglycoside antibiotic. Which of the following diuretics should be avoided, for this patient?
Both the loop diuretics and the aminoglycosides (tobramycin, streptomycin, gentamicin, others) are potentially ototoxic—capable of causing vestibular damage (e.g., balance problems) or cochlear damage (tinnitus or, in some cases, sensorineural hearing loss). The ototoxic effects of each drug are enhanced (often significantly) by the other’s. The loop diuretic is an example of a drug that can cause several drug- drug interactions.