Oncology and Fibroids
A pregnant 35-yrs-old patient is at highest risk for the concurrent development of which of the following malignancies? (AIIMS Nov 2010)
a. Cervical cancer is a more common gynecologic malignancy in pregnancy than ovarian or breast cancer due to the fact that it is a disease of younger women.
b. Management of cervical intraepithelial lesions is complicated in pregnancy because of increased vascularity of the cervix and because of the concern that manipulation of and trauma to the cervix can compromise continuation of the pregnancy.
c. A traditional cone biopsy is only indicated in the presence of apparent microinvasive disease on a colposcopically directed cervical biopsy Otherwise, more limited procedures such as shallow coin biopsies are more appropriate.
d. If invasive cancer is diagnosed, the decision to treat immediately or wait until fetal viability depends in part on the gestational age at which the diagnosis is made and the severity o disorder. Survival is decreased for malignancies discovered later in pregnancy Radiation therapy almost always results in spontaneous abortion, in part because the fetus is particularly radiosensitive. Chemotherapy is associated with higher than expected rates of fetal malformations consistent with the antimetabolite effects of agents used. Specific malformations depend on the agent used and the time in pregnancy at which the exposure occurs.