A pregnant female, just diagnosed to be HBS Positive what is the Best Management? (AIPG 2009)
|A||Anti HB vaccine to neonate|
|B||Immunoglobulins to neonate|
1. Vertical transmission of Hep B is 10 percent in mothers with negative HBeAg and positive HBeAb
2. Its 90 percent in those with positive HBeAg.
3. The risk of chronic hepatitis B virus infection ina neonate who does not receive immunoprophylaxis and vaccination for hepatitis B virus is 40 percent.
4. Neonatal hepatitis B virus infection is rare if maternal infection takes place in the first trimester.
5. The infection occurs in 6 percent of neonates of women infected in the second trimester
6. In 67 percent of those infected in the third trimester and in virtually all of those infected in the immediate postpartum perioD.
7. Infants of HBsAg-positive mothers should receive hepatitis B immune globulin immunoprophylaxis at birth and hepatitis B vaccine at one week, one month and six months after birth.
8. Administration of HBV along with HBIG does not diminish the immunologic response to the vaccine.
9. The combination increases the protection conferred to the infant to 90 to 95% as compared
10. to 75 to 85% when the HBIG is used alone.
11. Then timing of HBIG is more important than HBV to ensure immunization competence.