General Virology and DNA Viruses
A previously healthy 8-year-old boy develops a classic childhood illness as a result of a primary viral infection. Which of the following agents would most likely produce symptomatic disease in a boy of this age? (AIIMS May 2010)
|B||Epstein-Barr Virus (EBV)|
|C||Herpes simplex virus 2 (HSV-2)|
|D||Varicella-zoster virus (VZV)|
a. VZV is a classic childhood disease that produces symptomatic primary infections; answers A, B, C are incorrect:
b. Most primary CMV, EBV, and poliovirus infections are asymptomatic, whereas HSV-2 infections would rarely occur in a child of this age.
c. VZV causes 2 distinct clinical disease:
d. Varicella (chickenpox) - benign illness of childhood
e. Herpes zoster(Shingles) - Occurs with reactivation of VZV in old age
- Acute inflammation of one / more DRG.
i. When VZV involves ophthalmic division (reactivation in trigeminal ganglia) of 5th nv. - Ophthalmic zoster (Herpes zoster ophthalmicus)
ii. When VZV involves facial nerve. (Reactivation of VZV in the geniculate ganglion) + eruptions on ipsilateral tympanic membrane / EAM (external auditory meatus) facial palsy often associated with loss of taste in the anterior tongue tinnitus, hearing loss and vertigo - Ramsay Hunt syndrome
iii. Residual pain neuropathic pain in dermatomes of affected sensory ganglia - postherpetic neuralgia