General Virology and DNA Viruses
A transplant patient taking high levels of immunosuppressive drugs becomes infected with EBV and develops a lymphoma. The dosage of immunosuppressive drugs given to the patient is subsequently decreased, and the tumor regresses. Which of the following properties of EBV infection is related to the patient's tumor development? (AIPG 2010)
|A||Immortalization of B cells|
|B||Increased white blood cell count|
|C||Presence of atypical lymphocytes|
|D||Production of heterophile antibodies|
a. Aggressive monoclonal B-cell lymphomas can develop in patients with reduced T-cell function.
b. The immortalization/ transformation of B cells in the absence of functional T cell immunity can give rise to lymphoproliferative disease such as Hodgkin lymphoma, Burkitt lymphoma, and nasopharyngeal carcinoma.