A triad of seizure, mental retardation and sebaceous adenoma is seen in (AIIMS Nov 2012)
o lt is an autosomal dominant neurocutaneous syndrome.
• Characteristics brain, lesion, consists of tubers in the brain.
• They are typically present in subependyneal region where they undergo calcification producing candle dripping appearance.
Clinical manifestation of tuberous sclerosis
Infants During childhood
Infantile spasms, which may o Coeneralized seizure disorder.
develop into myoclonic epilepsy. o Adenoma Sebaceum (tiny red
Hypopigmented skin lesions (ash nodules over nose and cheeks).
leaf spots) o Shagreen patches
o Rhabdomyoma of heart
o Hamartomas in kidney
o Angiomyolipomas in lung.
o Mulberry tumours in retina.
o Mental retardation