A young male on atracurium on ventilator for 3 days develops epilepsy. What is the cause of epilepsy? (AIPG 2007)
|A||Too much ventilation|
a. Atracurium is a acidic compound
b. Onset of action - 2-3 minutes
c. Duration of action - 10-15 minutes
d. It is the muscle relaxation of choice in hepatic failure, renal failure and myasthenia gravis
e. Other side effects - hypotension and bronchospasm due to histamine release. It also causes allergic reaction.
f. Muscle relaxants causing histamine release - MAST - Mivacurium, Atracurium, Succinyl choline and tubocurarine.
g. One of its metabolite is epileptogenic →Laundosine