A young male with LDL 600mg/dl & triglycerides 160mg/dl finding on physical examination is (AIIMS Nov 2011)
|B||Eruptive tuberous xanthoma|
Note: In this case only LDL is raised but Tg is normal. Hence it is cause of Type II A (Familial Hyper Cholesterolemia). Tendon xanthoma are seen in type II A. Eruptive tuberous xanthoma are seen in type II B and type III.
(Ref: Harrison’s Textbook of internal medicine, 18th ed. chapter 356)
1. Xanthoma is a deposition of yellowish cholesterol-rich material in tendons or other body parts in various disease states.
2. They are cutaneous manifestations of lipidosis in which there is an accumulation of lipids in large foam cells within the skin.
3. Histology picture of xanthoma shows lipid laden foam cells with large areas of cholesterol clefts,
4. They are associated with hyperlipidemias, both primary and secondary types.
5. Tendon Xanthoma are associated with Type II hyperlipidemia and chronic biliary obstruction.
6. Palmar xanthomata and tuboeruptive xanthomata (over knees and elbows) occur in Type III hyperlipidemia
7. Eruptive with Type V hyperlipidemia.