A young woman who has suffered recurrent abortions has a history of joint pains and fever. She now presents with thrombosis of leg veins and her APTT is prolonged. The most likely diagnosis is (LQ)
|A||Inherited protein C and S deficit|
|B||Factor VIII deficiency|
|C||Antiphospholipid antibody syndrome|
|D||Increased antithrombin III levels|
Antiphospholipid antibody syndrome
1. Antiphospholipid antibody syndrome - includes lupus anticoagulant (LAC) and anti cardiolipin antibodies (ACAs), they may be of IgG, IgM and IgA classes alone or combination, they also are associated with antiphospholipid antibody syndrome. Antiphospholipid antibodies and pregnancy - strong association with decidual vasculopathy, placental infarction fetal growth restriction, early onset preeclampsia, and recurrent fetal death.
2. Women have a high incidence of venous and arterial thrombosis, cerebral thrombosis, hemolytic anemia, thrombocytopenia and pulmonary hypertension.