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Medicine

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Endocrine

Question
20 out of 20
 

A young women with secondary amenorrhea and galactorrhea. MRI shows a tumour of < 10mm diameter in the pituitary fossa. Treatment is: (PGI May 2010)



A Hormonal therapy for withdrawal bleeding

B Radiotherapy
C Chemotherapy

D Bromocriptine
E Surgery

Ans. D

Bromocriptine

Treatment.

1). Trans-sphenoidal surgery: Usually the treatment of choice.

2). Medical:

Somatostatin analogues eg octreotide & Lanreotide. (Ref. Hari - 18th, ed., Pg 2896).

Dopamine agonist – Bromocriptine & cabergoline are also use.

3). Radiotherapy: If surgery inappropriate or as adjuvant; may take years to work,

a. GH Receptor Antagonist, Pegvisomant, antagonizes endogenous GH action by blocking peripheral GH binding to its receptor.

b. Consequently, serum IGF-I levels are suppressed, reducing the deleterious effects of excess endogenous GH. (PNQ) (Ref. Hari 18thed., Pg 2896)

Extra Edge: (Ref. Hari 18th ed., Pg 2882)

1). Carney syndrome is characterized by spotty skin pigmentation, myxomas, and endocrine tumors, including testicular, adrenal, and pituitary adenomas. Acromegaly occurs in about 20% of these patients.

2). McCune-Albright syndrome consists of polyostotic fibrous dysplasia, pigmented skin patches, and a variety of endocrine disorders, including acromegaly, adrenal adenomas, and autonomous ovarian function.

Endocrine Flashcard List

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