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Medicine

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Hematology

Question
9 out of 16
 

A17-year-old boy presented with TLC of 138x 109/ L with 80% blasts on the peripheral smear. Chest X-ray show a large mediastinal mass. Immunophenotyping of this patent's blasts would most likely demonstrate:



A No surface antigens (null phenotype)

B An immature T cell phenotype (Tdt/CD34/CD7 positive)

C Myeloid markers, such as CD 13,CD33 and CDl5

D B cell markers, such as CD19,CD20 and CD22

Ans. B

An immature T cell phenotype (Tdt/CD34/CD7 positive)

Characteristic Features of T cell ALL (20% of ALL)

1. Occurrence in older children (adolescents) and adult

2. Predilection for males

3. Presence of anterior mediastinal mass in upto half of the cases at presentation (thymic mass)

4. Early CNS involvement (Early dissemination to meninges and testes)

5. High WBC count often greater than 100,000/mm3

6. The presence of a mediastinal mass in a young adolescent male suggests the diagnosis of precursor T cell ALL.

7. Vii. Precursor T cell ALL is phenotypically characterized by an immature T cell phenotype and is positive for TDT and CD7 and may be positive for CD34.

Hematology Flashcard List

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