A35-year-old woman has Graves’ disease, a small goiter, and symptoms that are deemed “mild-to-moderate.” Propylthiouracil is prescribed. Which of the following is the most serious adverse response to this drug, for which close monitoring is required? (LQ)
|D||Renal tubular necrosis|
a. propylthiouracil, and methimazole cause agranulocytosis
b. The most common side effect is urticaria. It may abate spontaneously or require symptomatic management with an antihistamine (either first or second generation) or with a corticosteroid.
c. None of the other responses listed are recognized as being associated with thio-amides.