Loading....
Coupon Accepted Successfully!

Pharmacology

Open Flashcards

Cardiovascular Systems

Question
39 out of 84
 

ACE inhibitors which of the following is true?



A Inhibit angiotensinogen conversion to angiotension-I

B Omit diuretics to prevent 1st dose hypotension

C Enalapril is more long acting than lisinopril

D Can’t given till systolic dysfunction resolve

Ans. B Omit diuretics to prevent 1st dose hypotension. (Ref.: - KDT, 6th, 484.)

a. ACEI inhibit the conversion of AT – I to AT – II.

The drugs which prevent conversion of Angiotensinogen to AT- I are direct renin inhibitors like aliskiren and remikiren. (OPTION A.)

b. 1st dose hypotension is a one of the side effect of ACEI seen; they being powerful arteriolar dilators.

It is commonly seen in patients suffering from CHF & those, which are on vigorous diuretic therapy. Thus to avoid this effect; diuretics should be omitted. (OPTION B).

c. Enalapril is shorter acting than lisinopril; though both can be given OD. The duration of action of enalapril is 24 hrs while that for lisinopril is more than 24 hrs. The elimination half-life is 11 & 12 hrs respectively. (OPTION C.)

d. They are indeed, one of the first drugs to be given in systolic dysfunction. (OPTION D).

ACE inhibitors are the drug of choice:

· Diabetes with hypertension

· Nephropathy wit hypertension

· CHF

· Proteinuria

· Reno-vascular hypertension

· Unilateral renal artery stenosis

These drug improve left ventricular dysfunction hence are the front like drugs in CHF

Cardiovascular Systems Flashcard List

84 flashcards
1)
2)
3)
4)
5)
6)
7)
8)
9)
10)
11)
12)
13)
14)
15)
16)
17)
18)
19)
20)
21)
22)
23)
24)
25)
26)
27)
28)
29)
30)
31)
32)
33)
34)
35)
36)
37)
38)
39)
40)
41)
42)
43)
44)
45)
46)
47)
48)
49)
50)
51)
52)
53)
54)
55)
56)
57)
58)
59)
60)
61)
62)
63)
64)
65)
66)
67)
68)
69)
70)
71)
72)
73)
74)
75)
76)
77)
78)
79)
80)
81)
82)
83)
84)