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Medicine

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Respiratory

Question
24 out of 27
 

About mesothelioma all are true except

(AIIMS May 2011)



A Develop in late middle age

B It is bilateral and symmetrical

C It is due to chronic exposure to asbestosis

D It shows biphasic pattern

Ans. B

It is bilateral and symmetrical

Mesotheliomas

(Ref. Hari-18th ed., page 1978, 2124)

1). Mesotheliomas both pleural and peritoneal, are also associated with asbestos exposure.

2). In contrast to lung cancers, these tumors do not appear to be associated with smoking.

3). Relatively short-term asbestos exposures of ≤1–2 years or less, occurring up to 40 years in the past, have been associated with the development of mesotheliomas.

4). Although ~50% of mesotheliomas metastasize, the tumor generally is locally invasive, and death usually results from local extension.

5). Most patients present with effusions that may obscure the underlying pleural tumor.

6). In contrast to the findings in effusion due to other causes, because of the restriction placed on the chest wall, no shift of mediastinal structures toward the opposite side of the chest will be seen.

7). The major diagnostic problem is differentiation from peripherally spreading pulmonary adenocarcinoma or from adenocarcinoma metastasized to pleura from an extrathoracic primary site.

8). Although cytologic examination of pleural fluid may suggest the diagnosis, biopsy of pleural tissue, generally with video-assisted thoracic surgery, and special immunohistochemical staining is usually required.

9). Microscopically Malignant mesothelioma may be epithelioid (60%), Sarcomatoid (20%) or can be mixed i.e biphasic histology seen.

10). There is no effective therapy.

Respiratory Flashcard List

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