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Physiology

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Central Nervous System

Question
17 out of 18
 

About neuropeptide Y an orexin {appetite stimulant}:all are TRUE except: (AIIMS NOV 20100


A it is mediated under the effect of melanocortin

B decreases thermogenesis
C its level increases during starvation

D contains 36 aa residues

Ans. A it is mediated under the effect of melanocortin

a. Neuropeptide Y(NPY) is a 36-amino acid peptide neurotransmitter found in the brain and autonomic nervous system.

b. The main effect is increased food intake and decreased physical activity.

c. NPY is secreted by the hypothalamus, and, in addition to increasing food intake, it increases the proportion of energy stored as fat and blocks nociceptive signals to the brain.

d. NPY also augments the vasoconstrictor effects of noradrenergic neurons

e. NPY into the PVN results in an acute release of corticotropin-releasing hormone (CRH) in the rat brain, proving that NPYergic activity directly stimulates the release and synthesis of CRF.

Central Nervous System Flashcard List

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